Vitvitsky A.A.  

Computer simulation of self-organization MinDE protein system during bacterial cell growth and division

The MinCDE protein system is a regulation mechanism in E. coli bacteria, that prevents incorrect cell division [1]. Detailed properties of the proteins interaction are not yet quite clear.  Computer simulation of the process is a hard task because the available simulation tools have a poor efficiency  in case   when   the  structure of simulation space changes dynamically. In this work, a method of constructing an inhomogeneous 3D mesh to simulate dynamic (i.e. cell growth and division) of a bacterial cell surface with different form, has been proposed. Based on the proposed approach, cellular automaton model of self-organization MinDE proteins in E. coli bacteria has been developed. In contrast to the existing models [2], this model allows to simulate cell growth and division together with self-organization process and study interaction between them.
The project has been partially supported by RFBR under Grant 14-01-31425 mol_a.

1. Lutkenhaus J. Assembly dynamics of the bacterial MinCDE system and spatial regulation of the Z ring // Annu. Rev. Biochem. 2007. № 76. P. 539-562.
2. Bonny M., Fischer-Friedrich E., Loose M., et al. Membrane Binding of MinE Allows for a Comprehensive Description of Min-Protein Pattern Formation // PLOS Computational Biology. 2013. Т.9. №12. C.1–12

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